Claire K. Schultz begins the interview by discussing her childhood in south central Pennsylvania. Raised primarily by her father and grandmother, Schultz dreamed of becoming a doctor from a young age. Inspired by her grandmother's belief in her abilities, Schultz graduated from Juniata College in three years, and went on to medical school after a year of work in the Philadelphia State Hospital. Forced to leave medical school by the birth of her first child, Schultz went on to a job as a research assistant at the Wistar Institute of Anatomy and Biology, and then to Merck Sharp & Dohme [MSD], where she held her first position in a library.

Schultz's interest in information retrieval began at Merck Sharp & Dohme Research Laboratory, where she met Calvin Mooers. After talking to Mooers about his ideas regarding information retrieval, Schultz joined forces with Robert Ford, of MSD's Pharmacology Lab, and began a campaign to get an IBM 101 system at Merck Sharp & Dohme. Schultz wrote her master's thesis at Drexel University in Library Science on the MSD library system. While working at MSD, Schultz met John Mauchly, Eugene Garfield, and Peter Luhn. As one of the pioneer documentalists, Schultz worked at Sperry Rand Univac Corporation, and later at the Institute for the Advancement of Medical Communication, and taught various courses on information science at Drexel University and at the Medical College of Pennsylvania. Schultz closes her interview with anecdotes about her post-retirement hobbies, and her work as a computer consultant in a local elementary school.